Skip to main content

Purine base pairs with purine & pyrimidine with pyrimidine!!!!?

Hi,
I started learning molecular biology this semester! And, I'm very happy about it. As I love Cell and micro biology, I started loving molecular biology too. :)

My very first beginning with molecular biology is DNA. We all know very well about the structure of DNA as proposed by Watson, Crick, Rosalind Franklin & Maurice Wilkins. 

Certain basics about DNA:
1) DNA is Double stranded and acidic. They have four nitrogenous bases ATGC (Adenine, Thymine, Guanine, Cytosine), Deoxy Ribose, Phosphate. A&G are purines. C&G are pyrimidines.
2) The acidic charge is due to the phosphate group which is protruding out of the DNA.
3) A always basepairs with T & C with G. Between A&T there is a double bond of hydrogen. And, triple hydrogen bond between C and G.
i.e., Purine basepairs with pyrimidine or the viceversa.

But, why not a purine and purine, a pyrimidine and pyrimidine?

Mm... Why not??!

It won't. Because, when a purine and purine base pairs that region would be somewhat wide, due to the bulkiness of purines.

If pyrimidine and pyrimidine, that region would be so narrow. Imagine, this will lead to an irregularity in the DNA's structure. It will appear something like this. (Bulky and narrow, bulky and narrow.)

:D :D See how beautiful this irregular DNA is??? :) :) 
This won't be stable.
You know, when DNA is unwound, it will stretch into kms???!!!
Shh.... Don't reveal this secret to anyone. (DNA- Secret of Life) :P :P :)
Happy learning..! Bye. Bye.

Comments

Popular posts from this blog

Lowry Assay Principle and procedure

Though there are several protein assays available, the most preferred one in many laboratories is "Lowry assay". It is effective in the concentration range of 0.01 mg/ml to 1 mg/ml. And, as an additional info, the paper published describing the procedure and principle of Lowry Assay is the most cited paper in the scientific history. (Feeling like, "Wow! I want to publish one to compete with Oliver.H. Lowry"???  :P) Why Lowry?   Though there are several other protein assays, mostly Lowry assay is used in many laboratories. The reasons for preferring Lowry are: sensitivity of the assay, highly reproducible, cost effective, easy to perform. Biuret assay is generally used for higher protein concentrations like tissue samples but, Lowry for less concentrated samples and hence used in most of the molecular biology laboratories where there will be need for assaying comparatively less concentrated protein samples (in most cases where we attempt to produce enzymes). Oth

Sea Butterfly!

Neih hou!  Don't roll you eyes wondering what it is! "Neih hou" is how you say "hello" in Cantonese. Guess what, I am in Hong Kong and therefore the language Cantonese. I came to Hong Kong this summer as an intern before officially joining as a PhD Student. This is my second experience abroad, far away from home, new language, new culture, I expected me to have a "really" bad cultural shock, but, actually I experienced only 50% of what I expected. For a girl who have used the marina beach only for eating "sundal", bikini in beach was a shock (FEEL FREE TO JUDGE ME!). The first time, I went to the big wave beach here, I was the only one who was totally covered, when everyone was enjoying their Beer, I was slowly sipping my lemon juice (THE ODD ONE OUT!). I realized how beautifully different the world outside is! There is no single standard for right or wrong, it varies in different countries, in different regions around the world. And it

The Butterfly flew for the first time!

Hi dear sweet lovely reader, Didn't meet you for a long time... Just after complaining about the stipend problem in the last post, I actually wanted to write a lot here, but, couldn't find time (Such a lazy girl, I am!). As you might be knowing, the author (me) is the butterfly here :P And, I flew for the first time!! YEAH! I FLEW! I flew like a butterfly! It was an awesome experience flying for the very first time! (ow, no! I dint put a trans-gene in my body and fly after getting  a pair of wings, but with a passport and VISA). I'm this girl, full of dreams wishing to do "this", "that" and "all kind of stuffs that one can do". And, one among those dreams was to fly one day! TO FLY FREE!(I mean, not free of cost :P, but liberation) I always wanted to fly in those big, big airplanes, but, I always have avoided that mode of transport. Reason? Obviously, it would burn a big hole in my dad's pocket (actually he can afford if I wan